Quercetin, a flavonoid widely distributed in nature (apples, onions, green tea, etc) has previously been shown to increase energy expenditure in rats, but only for short periods (fewer than 8 weeks). Effects of quercetin on exercise tolerance in mice have been associated with increased Mitochondrial biogenesis. In mice, an oral quercetin dose of 12.5 to 25 mg/kg increased gene expression of mitochondrial biomarkers and improved exercise endurance. A paper released in the Jour