@2017 by Performance Genetics LLC

New MtDNA study reveals closer genetic and pedigree links

A decade ago Emmeline Hill, Dr Patrick Cunningham and others from the Trinity College in Dublin published a seminal paper on thoroughbred mitochondrial DNA. The paper, which caused some controversy at the time showed that the maternally inherited mitochondrial DNA (mtDNA) did not correspond with pedigree records, that is, as good a job that Bruce Lowe, Bobinski and Shirai had done, the pedigree records were inaccurate at some point in time. Hill found that almost half of the female families, which are each considered from pedigrees to have matrilines converging to one of >30 historically recognized female ancestors, contained sequences which were inconsistent with common descent. A great ou

The High Scoring Horse

We are often asked the question....'if you were using these tests to buy your own horses, which ones would you buy?" Not a bad question to ask....sort of like, put your money where your mouth is. The answer is actually one that we have researched quite extensively. In statistical terms it hovers around the measures of performance of sensitivity and specificity. We have talked about this before but sensitivity measures the proportion of actual positives which are correctly identified as such (e.g. the percentage of elite racehorses who are correctly identified as being elite) while specificity measures the proportion of negatives which are correctly identified (e.g. the percentage of non-elit

Clenbuterol and drug regulation in American racing

The drug Clenbuterol is a β2 agonist with some structural and pharmacological similarities to epinephrine (adrenaline). Therapeutically, clenbuterol is a fantastic bronchodilator and has been approved by the FDA for use in horses for the management of airway obstruction. If a horse has mucus in the throat there is nothing better on the market that can clean it up and help the horse get to the racetrack. That is the good. Clenbuterol is also the drug that cyclist Alberto Contador of Spain was banned for two years from professional cycling after testing positive for at the 2010 Tour de France. It is the drug that former New York Mets clubhouse employee Kirk Radomski admitted in his plea deal t